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Arterial Hypertension: Pathogenesis, Diagnosis, and Therapy by W. M. Manger, I. H. Page (auth.), Julian Rosenthal M.D.

By W. M. Manger, I. H. Page (auth.), Julian Rosenthal M.D. (eds.)

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Circ Res 30:257-262 ° 32 W. M. Manger, I. H. Page pertension. 3 In: Genest J, Koiw E, Kuchel 96. Fitzsimons JT, Simons BJ (1969) The effect on drinking in the rat of intravenous infusion of angioo (eds) Hypertension. McGraw-Hill, New York, pp 559-566 tensin, given alone or in combination with other stimuli of thirst. J Physiol 203:45-57 114. Genest J, Boucher R, Kuchel 0, Nowaczynski W 97. Folkow B (1971) The haemodynamic consequences (1973) Renin in hypertension: how important as a of adaptive structural changes of the resistance of risk factor?

10). In one study, administration of indomethacin (which blocks prostaglandin PROSTAGLANDIN DEFICIENCY I SYSTEMIC DEFICIENCY ==:::==~:£:+----+ RENAL PRESSOR FACTORS --+ (] } } ) ) ) ) ) ) } ) ) ) PERIPHERAL ARTERIOLAR VASOCONSTRICTION ~ KIDNEY SUSTAINED HYPERTENSION Figure 10. Schematic representation of a hypothetical role for a deficiency of intrarenal prostaglandins in the establishment of sustained hypertension. From Lee JB, ref 198, p 1078 1: Overview of Current Concepts Regarding the Pathogenesis and Pathophysiology of Hypertension synthesis) to patients with uncomplicated essential hypertension had little effect on blood pressure.

Ball JH, Kaminsky NI, Hardman, JG, Broadus AE, Sutherland EW, Liddle GW (1972) Effects of catecholamines and adrenergic-blocking agents on plasma and urinary cyclic nucleotides in man. J Clin Invest 51:2124-2129 13. Barrientos A, Alcazar JM, Ruilope LM, FernandezTresguerres J, Garcia Robles R, Jarillo MD, Rodicio JL (1978) Effects of indomethacin in essential hypertension (abstr). Internat Soc Hypertension, Fifth Scientific Meeting, p 25 14. Beevers DG, Campbell BC, Goldberg A, Moore MR, Hawthorne VM (1976) Blood-cadmium in hypertensives and normotensives.

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