By Priv.-Doz. Dr. med. Rainer Haas, Dr. med. Ralf Kronenwett, Priv.-Doz. Dr. rer. nat. Georg Sczakiel (auth.)
This e-book supplies an summary of the present cutting-edge in peripheral blood stem cellphone transplantation and up to date advancements in molecular prognosis and gene healing techniques. the focal point is at the function of peripheral blood stem mobile transplantation within the therapy of hematological malignancies corresponding to non-Hodgkin lymphomas, persistent myelogenous leukemia and a number of myeloma. present molecular organic concepts for detecting genetic defects in tumors and minimum residual sickness also are offered. extra issues comprise new gene healing recommendations in hematology and oncology: using viral vectors for transduction of hematopoietic cells is mentioned in addition to healing suggestions in response to antisense nucleic acids, ribozymes, and immunological approaches.
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Additional info for Advances in Hematopoietic Stem Cell Transplantation and Molecular Therapy
Goldschmidt 1, U. Hegenbart 1, M. Wallmeier 1, S. Hohaus J, R. Engenhart 2 , M. Wannenmacher 2 , and R. Haas J Department of Internal Medicine V, University of Heidelberg, HospitalstrafSe 3, 69115 Heidelberg, Germany 2 Department of Radiology, University of Heidelberg, 1m Neuenheimer Feld 400, 69120 Heidelberg, Germany 1 Abstract The objective of our study was to evaluate the efficacy and toxicity of a highdose melphalan-based therapy with or without total body irradiation (TBI) followed by peripheral blood progenitor cell (PBPC) transplantation in patients with multiple myeloma.
The actuarial overall survival for the entire group was 53% at 3 years. The major factor for predicting outcome after transplantation was disease status: the 3-year actuarial overall survival was 72% for patients undergoing transplantation during the first CR, compared with 37% for patients in chemosensitive relapse and 7% for chemoresistant patients. For patients undergoing transplantation during first CR, disease bulk at the time of ASCT was the only factor predictive of progression-free and overall survival.
Haas J Department of Internal Medicine V, University of Heidelberg, HospitalstrafSe 3, 69115 Heidelberg, Germany 2 Department of Radiology, University of Heidelberg, 1m Neuenheimer Feld 400, 69120 Heidelberg, Germany 1 Abstract The objective of our study was to evaluate the efficacy and toxicity of a highdose melphalan-based therapy with or without total body irradiation (TBI) followed by peripheral blood progenitor cell (PBPC) transplantation in patients with multiple myeloma. Between June 1992 and June 1996, 104 patients (71 male, 33 female) with a median age of 51 years (range 30-65 years) underwent transplantation at our center.