By E. G. Snyderwine (auth.), Prof. Dr. med. Hans-Jörg Senn, Richard D. Gelber Ph.D, Prof. Dr. med. Aron Goldhirsch, Priv.-Doz. Dr. med. Beat Thürlimann (eds.)
This quantity offers an up to date survey of present laboratory and, generally, medical study at the diagnostic and treatments in basic breast melanoma. The chapters derive from the invited specialist lectures provided on the sixth overseas convention on fundamental Breast melanoma held in St. Gallen, Switzerland, in February 1998. the global breast melanoma neighborhood has been eagerly watching for this quantity and its consensus platform and suggestions. there's no replacement to this assembly and booklet within the box of adjuvant remedy of basic breast cancer.
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Additional info for Adjuvant Therapy of Primary Breast Cancer VI
The molecular genetic profile of the tumour has prognostic value, but more importantly it can be used to predict tumour behaviour and response to therapy. Thus, cancers with p53 gene mutation have been shown to have a worse prognosis and are resistant to DNA-damaging chemotherapeutic agents. It is essential that in the future we can profile all the abnormalities in a tumour and know their functional significance. This is a long way off, but it is the aim for the future. By profiling tumours and checking their profile against clinical follow-up in large clinical trials we will be able to identify the key combinations responsible for the clinical phenotype.
Finally, the new SERM LY353381· HCI has been reported to be a potent estrogen antagonist in breast and uterus, an estrogen agonist in bone and cardiovascular tissues, and to be very effective in inhibiting mammary carcinogenesis in rats (Sporn et al. 1997). Conclusions Prevention is clearly one of the doors we have to go through in order to arrive to the unfolding and solving of the cancer problem. Today we know much more about the various aspects of the long and complex carcinogenic process leading to that final entity which is breast cancer.
1992). Estrogen/Hormone Replacement Therapy and the Etiology of Breast Cancer 25 Others have pointed out that estrogen use in postmenopausal women effects not just lipid levels. It is estimated by modeling studies that only about 40% of the beneficial effect of estrogen on cardiovascular outcome may be related to changes in lipid levels. Estrogen also has direct effects on vessel walls, on myocardium, and of course on platelets (Lobo 1991). Thus, drugs such as the various lipid-lowering agents, which presumably act on lipids alone, may not be able to replace ERT/HRT in producing this effect.